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KMID : 0391419960060010035
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Korean Journal of Lipidology
1996 Volume.6 No. 1 p.35 ~ p.42
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Effect of Hormone Replacement Therapy for 1 Year on Lipoprotein(a) and Lipids in Postmenopausal Women
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김치정
이광제/정유석/민용기/유왕성/유언호
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Abstract
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recent reports have shown that lipoprotein(a)[Lp(a)] is associated with female sex hormones. Estrogen and/or progesterone decreased Lp(a) levels. However, these studies had small number of cases, follow-up for short duration, or comparisons of
one
or
two regimens. Effect of estrogen on lipids is obvious. However, combined therapy of estrogen and progesterone is controversial. Therefore, this study was conducted to evlauate the effect of administration of various female sex hormones for 1 year
on
Lp(a) and lipids.
One hundred and eight one postmenopausal women were divided into four groups : Group A (n=42); conjugated equine estrogen(CEE) 0.625mg+medroxyprogesterone(MPA) 10mg, Group B (N=44); CEE 0.625mg+MPA 5mg, Group C(N=24); CEE 0.625mg in
hysterectomized
women, and Group D(N=30); control. Lp(a) and lipids were measured before and 1 year after medication.
Lp(a) level were reduced by 17.7%, 27.0%. and 38.6% in group A, B, and C respectively. there were no statistically significant differences in the effectiveness among three groups although estrogen therapy(group C) showed the most profound
decrease.
High
density lipoprotein cholesterol(HDL-C) was elevated by 16.1% and 22.7% in group A and C, and not changed in group B. Low density lipoprotein cholesterol levels were decreased in all treated groups by 12.7~15.7%.
In conclusion, Lp(a) lowering effects of estrogen therapy in postmenopausal women were persistent for 1 year and it might be one of mechanisms of cardioprotective effect f estrogen. The combined therapy of progesterone with estrogen might
abolished
the
effect of estrogen by unfavorable influence on HDL-C and Lp(a).
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KEYWORD
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